The effects of different doses of amantadine on lung tissue in lower extremity ischemia reperfusion injury in rats

Aim: Ischemia/reperfusion (I/R) injury is a common complication after abdominal aortic surgery. N-Methyl D-Aspartate (NMDA) antagonists protect many organs against to I/R injury. Therefore, in this study, we aimed investigate the effects of 135 mg/kg and 90 amantadine, on lung tissue lower extremity rats.
 Material Methods: 36 wistar rats were randomly divided into 6 groups each containing six as follows; Sham group (Group S), Amantadine A-90), A-135), Ischemia/Reperfusion I/R), + I/R-A 90), 135). At end procedure, all sacrificed, their tissues obtained. Lung examined biochemical histopathologically.
 Results: The catalase, superoxide dismutase activities malondialdehide levels similar between groups. neutrophil/lymphocyte infiltration score higher Group than S, A-90 A-135. Alveolar wall thickening A-90, A-135 135. 
 Conclusion: Although could not find statistically significant difference values, observed that was histopathologically affected by damage less with amantadine use. In reduction damage, administration more beneficial mg/kg.